THE FORMULA
Every ingredient in Peridot Four capsules is carefully selected
for purity, quality, and synergy. We prioritize responsibly
sourced botanicals and transparent sourcing practices
because what we put into our body matters.
Our formulation is built on thoughtfully chosen plant compounds designed to support digestive wellness, metabolic balance, and
whole-body vitality without unnecessary additives or fillers.
Four Ingredients. Thoughtfully Selected.
BITTER MELON
It contains important plant compounds including charantin, vicine, polypeptide-P, and flavonoids, which have been studied for their role in supporting metabolic and cellular pathways particularly those involved in glucose metabolism and insulin signaling.
Bitter melon is a tropical fruit recognized for its rich profile of bioactive compounds.
These naturally occurring compounds may help support:
• Healthy metabolic balance
• Cellular antioxidant protection
• Hormonal balance
• Digestive and liver function
• Gut integrity and digestive wellness
Through its unique phytochemical profile, bitter melon supports the body’s natural ability to maintain metabolic equilibrium and internal balance.
Within Peridot Four, bitter melon is thoughtfully included as part of a low-histamine, synergistic botanical formulation designed to work in harmony with the body’s natural systems and support daily vitality.
GRAVIOLA LEAF
Graviola leaf is a tropical botanical traditionally valued for its rich
concentration of plant-based compounds that support
overall wellness.
Naturally occurring phytochemicals found in graviola including
acetogenins, flavonoids, and polyphenols have been studied for
their ability to support metabolic balance, cellular health, and
antioxidant protection.
Graviola is naturally low in histamine and is thoughtfully included in Peridot Four capsules as part of our balanced, plant-based formulation designed to work in harmony with the body’s natural systems.
This botanical contributes to:
• Metabolic balance
• Healthy cellular function
• Antioxidant protection
• Immune system support
• Overall vitality and wellness
With Peridot Four, graviola plays an important role in supporting the body’s natural ability to maintain equilibrium and resilience.
Soursop Fruit-(Annona muricata fruit)
Soursop is a tropical fruit valued for its naturally rich concentration of plant compounds that support overall wellness and vitality.
It provides a concentrated source of naturally occurring phytonutrients, including acetogenins, alkaloids, and vitamin C, which have been studied for their role in supporting cellular metabolism, antioxidant pathways, and metabolic balance.
Within Peridot Four, soursop is thoughtfully included to help support:
• Healthy cellular function and integrity
• Protection against oxidative stress
• Balanced metabolic processes
• Hormonal and digestive wellness
• Gut health and natural detoxification pathways
Soursop is naturally low in histamine and complements the synergistic botanical formulation of Peridot Four, designed to work in harmony with the body’s natural regulatory systems.
When incorporated into a balanced lifestyle, this tropical botanical supports the body’s innate ability to maintain equilibrium, vitality, and overall wellness.
Germanium Sesquioxide
Bis(2-carboxyethylgermanium sesquioxide) [Ge-132-US]
Product Overview
The synthesis of germanium sesquioxide was first published by Mironov, a Russian scientist, in 1967 [11]. Japanese scientists reported the same compound in respected literature seven years later [1]. However, Dr. Asai Institute in Japan was the first to capitalize on the biological activity by marketing it as a
true organic germanium compound. For this reason, Dr. Asai is
often mistakenly attributed with having discovered
germanium sesquioxide.
Applications include immune support and general health and
wellness. Gross contamination in early Asian material led to
import restrictions that prevent this compound from legally entering
the U.S., but not from being sold.
Designed Nutritional Products is your only domestic source.
Dietary Benefit
Germanium sesquioxide helps support the body’s natural immune defenses [1,2,3,13]. Germanium helps maintain the body’s natural production of gamma interferon and natural killer cells [2,4,12]. Studies indicate that Germanium exhibits antioxidant potential [5-7].
Stability
Germanium sesquioxide is light and temperature stable. No degradation has ever been reported in liquid or solid form.
Alternate Names
Bis (2-carboxyethylgermanium sesquioxide), Mu-trioxo-bis [betacarboxyethyl] germanic anhydride, Germanium sesquioxide, Ge-132, SK818, propagermanium, Organic germanium.
Classification
Germanium sesquioxide
CAS Registry Numbers [12758-40-6] and [27031-31-8]
Regulatory Status
Germanium sesquioxide is a dietary supplement under provisions of U.S. Dietary Supplement Health and Education Act of 1994 (DSHEA).
No studies exist demonstrating any toxicity associated with reasonable dosages of pure Germanium sesquioxide. However, inorganic forms such as germanium dioxide or germanium-lactate-citrate may cause acute renal failure.
REFERENCES
1. K. Asai et al., 1974 U.S. .Patent 3, 793, 455.
2. N. Kumano, et al., 1985 Tohoku J. Exp. Med., 146, 94-104.
3. Shoji Y., et al., 1985 Int. J. Immunother. 1: 215.
4. Ishida N. et al., 1984 U.S. Patent 4, 473, 581.
5. Masaki Y, et al., 1989 Transplantation Proceedings 21:1250-1251.
6. Wakabayashi Y. Biosci. 2001 Biotechnol Biochem 65(8):1893-1896.
7. Yang MK, Kim YG. 1999 Journal of Toxicology and Environmental Health ;12(58):289-297.
8. Y. Ishiwata, et al., 1990 Arcnein Forsch Drug Res. 40 (II), Nr. 8, 896-899.
9. Mainwaring MG, et al. Chest 2000;117:591-593.
10. Suzuki F., et al., 1986 Chemotherapy, Tokyo 34:448.
11. V.F. Mironov, et al., 1967 Zh. Obshch. Khim. 37 (4), 962, (911-912 in English trans).
12. G. Suzuki, et al., 1984 J. Interferon Research 4, 223-33.
13. Jang J.J. et al., 1991 Carcinogenesis 12: no4, 691-695
Notes
*Organic germanium: The term “Organic” is used to describe the presence of a germanium carbon bond and differentiate between dangerous “inorganic” forms lacking this feature.
More Info on U.S. Manufactured Organic Germanium
Germanium Sesquioxide Analytical Tests
Currently, there’s no published research showing that GE-132-US raises histamine levels in humans or animals.
Designed Nutritional products has registered with the U.S. Food and Drug Administration pursuant to Section 305 of the United States Public Health Security and Bioterrorism.
Preparedness and Response Act of 2002, P.L.107-188, such registration having been submitted with the registrant’s authorization by FDA Registrar Corp.
U.S. FDA Registration No.:14011365240
Effective date of registration: November 10, 2003